Buy Methadone 40 mg online cheap and best pills
Buy Methadone 40 mg online cheap and best pills is used to treat addiction to opioids as part of an approved treatment program.
Buy Methadone 40 mg is a white, crystalline material that is water-soluble.
Buy Methadone 40 mg is chemically described as 6-(dimethylamino)-4,4-diphenyl-3-hepatanone hydrochloride.
Its molecular formula is C21H27NO · HCl and it has a molecular weight of 345.91. Buy Methadone 40 mg has a
melting point of 235°C, and a pKa of 8.25 in water at 20°C. Its octanol/water partition coefficient at pH 7.4 is 117.
A solution (1:100) in water has a pH between 4.5 and 6.5.
Mechanism of Action:
Buy Methadone 40 mg is a mu-agonist; a synthetic opioid analgesic with multiple actions
qualitatively similar to those of morphine, the most prominent of which involves the central
nervous system and organs composed of smooth muscle.
The principal therapeutic uses for
methadone are analgesia and detoxification or maintenance in opioid addiction. The methadone
abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is
slower, the course is more prolonged, and the symptoms are less severe.
The Use of Opioid Analgesic Agents for Chronic Pain:
Opioid analgesic agents are safe and equally effective if prescribed appropriately and
administered in equipotent doses. Equipotency can be complicated because opioids differ in
half-life, binding affinity, route of administration, metabolism and potential for side effects.
In addition to the differences in the opioids themselves, an individual patient’s response to
opioid analgesics is variable and difficult to anticipate because of genetic differences that
influence analgesia and side effect profiles.
Buy Methadone 40 mg is contraindicated in patients with a known hypersensitivity to Buy Methadone 40 mg or any other
ingredient in DOLOPHINE.
Methadone is contraindicated in any situation where opioids are contraindicated such as: patients with respiratory
depression (in the absence of resuscitative equipment or in unmonitored settings), and in patients with acute
bronchial asthma or hypercarbia.
Buy Methadone 40 mg is contraindicated in any patient who has or is suspected of having a paralytic ileus.
INDICATIONS AND USAGE:
1. For the treatment of moderate to severe pain not responsive to non-narcotic analgesics.
2. For detoxification treatment of opioid addiction (heroin or other morphine-like drugs).
3. For maintenance treatment of opioid addiction (heroin or other morphine-like drugs), in conjunction with
appropriate social and medical services.
The elimination of methadone is mediated by extensive biotransformation, followed by renal and
fecal excretion. Published reports indicate that after multiple dose administration the apparent
plasma clearance of methadone ranged between 1.4 to 126 L/h, and the terminal half-life (T1/2)
was highly variable and ranged between 8 to 59 hours in different studies. Since methadone is
lipophilic, it has been known to persist in the liver and other tissues. The slow release from the
liver and other tissues may prolong the duration of methadone action despite low plasma
Maintenance patients on a stable dose of methadone who experience physical trauma, postoperative
pain or other acute pain cannot be expected to derive analgesia from their existing dose of methadone. Such patients
should be administered analgesics, including opioids, in doses that would otherwise be indicated for nonmethadone-treated patients with similar painful conditions. Due to the opioid tolerance induced by methadone, when
opioids are required for management of acute pain in methadone patients, somewhat higher and/or more frequent
doses will often be required than would be the case for non-tolerant patients.
Safety and effectiveness in pediatric patients below the age of 18 years have not been established.
Accidental or deliberate ingestion by a child may cause respiratory depression that can result in death. Patients and
caregivers should be instructed to keep methadone in a secure place out of the reach of children and to discard
unused methadone in such a way that individuals other than the patient for whom it was originally prescribed will
not come in contact with the drug.